SAFE Identity and DirectTrust share common histories as PKI trust frameworks that owe their existence to a collaboration with Federal Agencies. Particularly if one compares SAFE-BioPharma (the SAFE precursor trade association) to DirectTrust, our mission, vision, and core policies align around instilling trust between organizations. Both Trust Frameworks have a healthcare focus and are membership organizations that develop and maintain policy. For DirectTrust, assuming SAFE’s assets can be a catalyst for growth into new use cases like consumer identity credentials and pharmacy supply chain security. Incorporating SAFEs workgroups into ours, existing conversations with CARIN and PDG as well as new use cases for PKI like medical device security, and clinical research will be accelerated.